Daneshvar Medicine: Basic and Clinical Research Journal
Year:2002 | Volume:10 | Issue:41 (Special Edition on Medical Sciences Articles)|Papers Count:11

The introduction of GnRH-a in to the IVF field was a modern management which reduced premature LH-surge from 20% to 2% and improved the results of ovarian stimulation and its outcome during IVF cycles. However administration of GnRH-a is associated with ovarian cyst formation about 8-50% (22). The mechanism of cyst formation after GnRH-a administration is not fully understood. Some authors suggested that this phenomenon may be related to the release of Gondadotropins due to the initial up regulation or flare phase. Relation between these cycst, age and basal FSH are controversial. The aims of this study are assessment of frequency rate and relation between these factors (Age and basal Hormones) and cyst formation during suppression phase. 491 patient who underwent IVF or ICSI in a long protocol, were studied retrospectively. In all of whom after performing trans-vaginal sonography (TVS) on 21st day Busereline cycle, of was started (suprefact 0.5ccdaily, subcutaneous) and after, 2 weeks another TVS was done for evaluation of suppression. (Endometrial thickness <6mm+quiet ovaries or Estradiol <50 pg/ml). Cystis structures ≥20mm defined were as cysts. After complete suppression, stimulation was started as routinely in a long protocol. Age and basal FSH were recorded compared and between two groups (with cyst and without cyst) using X2, t test and Fishers exact test. results: The overall frequency rate of cyst formation in our patients population was 9.5%, There were no significant differences between two groups in the age (30.4±5.7 in group with cyst vs 30.8±5.7 in group without cyst) and basal FSH (6.01±3.4 in group with cyst vs 30.8±5.7 in group without cyst) and The overall frequency rate of cyst formation in our patient population (9.5%) was in the lower range reported by the researcher (8-50%). This likely is due to a number of variables including follicular or luteal phase initiation of Buserlein and the cut off for the cysts diameter. Although some studies have shown age and basal FSH (the two important indices for ovarian response) have positive correlation with cyst formation, this study didn’t show any relation between them. Further studies are needed to determine whether these cysts have any effect on IVF outcome or not.

Research studies have recently made it clear that the outbreak of cardial diseases is nearly twice among diabetic patients (Type I) as compared to the healthy people. Atrosclorosis is considered the most noticeable effect of diabetes. Yet, the unstable effects and aerobic exercise have improved the efficacy of the blood circulation system for several years. This effect is due to the dominant metabolism of betoxiditation during the endurance exercise as the increase in (Max V02) or (MET) and other hemodynamic actions. This will lead to different responses in cardiovascular system based on: career, severity, duration and the rate of exercise, and whether the person in physiologically prepared or not.In order to study the effect of submaximal aerobic exercise (Intensity in 56% HRR, 30-70% HRR) on the function of oxygen transport system in diabetic patient, 25 patients aged 18 to 28 were randomly selected who underwent daily insulin injection (48.8 pmol).The recorded average time among the diabetes was 5 years, 46.5 to 55.7 ml/kg/min practical capacity used, between two different groups (15 experimental and 10 Just to control) simply and accidentally. As two diabetes didn't use insulin and drugs, so they were omitted by the researchers.The physical indication of control and experimental groups was as fallows: age 21.4±3.37, 20.38±3.06 year), weight (64.90±16.70, 61.58±5.79 kg), height (165.75±6.31),(166.88:±6.27 cm), BMI (1.06±0.01,1.06±0.006 gr/cc).The experimental group used special interval aerobic practice during 9 weeks (2 times each week and also each time 30 to 60 mins). The performance factors of the heart and vein apparatus (O2f, sv, RPP, Vo2Max, HR. Recovery, performance time) of the experimental groups were measured before and after the application of dependent variable and the control groups were measured before testing by the use of the Bruce protocol of submaximal treadmill. The dependant and independent groups were considered by the statistical methods of MANOVA and also the relationship between the factors of multivariate analysis of regression.A significant increasing in O2P, SV and VO2max, performance time and also a significant decreasing in the HR, recovery were seen (P<0.005). Furthermore the decreasing variety of the RPP change in above patient while exercising aerobic with the average of the consumed oxygen 613 ml/kg/min is noticeable in clinical condition.Whatever has been found in this research shows that interval special submaximal aerobic exercise with 56% HRR intensity has central and environmental physiology in the heart and vein in diabetes (IDDM).

In 1995, life expectancy in Japan reached to more than 65 years old and in some European and North American countries it reached to even 80 years old. Moreover if the main aim of hygiene in the last century was only "to be alive", in this century it has been changed to "living with the best quality". The problems of old age cannot be treated in the elderly, but these problems such as eyesight and hearing loss and chronic diseases can be prevented by adequate planning in childhood, adolescence and young periods. That is by careful planning in these years and consequently proper use of physical, psychic and social capabilities the old age problems will be lessen. As old age is the result of interference of various physiologic, psychic and social factors, so its problems stem from the individuals themselves and they can be investigated and prevented providing that adequate knowledge, skill and time will be in access.In this analytic descriptive study the degree of knowledge and practice of 20-65 years old population in Kerman city in relation to old age hygiene have been studied based on demographic: features of age, sex, marital statues, number of possessed children, educational level and job. For this purpose city was divided into 30 regions and 23-24 individuals of each region that were selected by cluster sampling. Data were collected by using questionnaires that were distributed based on age pyramid in three age groups.Based on the results, there was significant difference among all three age groups in relation to knowledge and practice. The age group of 20-34 showed a better knowledge and practice in comparison to the other two groups (P<0.05). There was no significant difference in knowledge between men and women, but men had better practice than women (P<0.001). Unmarried subjects showed better knowledge and practice in comparison to married subjects (P<0.001). Subjects with higher educational levels showed better knowledge and practice (P<0.00l). In relation to job, those with official jobs had better practice (P<0.00l). In regard to knowledge about psychic health and practice in relation to physical psychic and social health, three age groups showed significant differences, in a sense that the age group of 50-65 had better knowledge and practice (P<0.001). Women showed better knowledge and practice in relation to psychic and social health in comparison to men (P<0.001) and also unmarried subjects and those without any children showed better practice in relation to physical, psychic and social health than married subjects and those with children (P<0.001). In regard to education, uneducated subjects had better knowledge about psychic health, whereas those with bachelor degrees or higher degrees had better practice in relation to physical, psychic and social health (P<0.05). Subjects with official jobs had better practice in physical psychic and social health  (P<0.00l).

The relative content of calcitonin gene-related peptide in lumb or motoneuron cell bodies (semi-quantitative immunohistochemistry) was examined in rats who had previously undergone for 16-weeks period of endurance training on a motor-driven treadmill. Soleus motoneurons were identified in the spinal cord by their fluorescence following injection of Fluorogold into the muscle one week before killing. In Sedentary rats, calcitonin gene-related peptide was detectable in 76-90% of motoneurons, with no difference in the proportions of negative cells, or in the mean staining intensity of positive cells, between soleus and neighboring (presumptive fast hindlimb muscle) unlabelled motoneurons. In endurance - trained rats, the estimated content of calcitonin gene-related peptide was significantly increased (90%) in cell bodies of soleus and neighboring motoneurons, with no training-induced alterations  in the proportions of calcitonin gene-related peptide positive cells in either sample. The increases in calcitonin gene-related peptide in motoneuron cell bodies following endurance training may indicate an up-regulation of the synthesis, transport and terminal release of this neuropeptide, which could play a significant role in other morphological and functional adaptations which are known to occur at the neuromuscular junction following the chronic change in activity level.

Weakness is the most common symptom of stroke that appears with various patterns relating to anatomic site of infarction. This study was carried out in 100 consecutive stroke patients, admitted in Emam Reza Hospital in Birjand in 2000-200l. Diagnosis, of stroke and motor exam was done by a neurologist and topography of cerebral infarction confirmed by topographic maps of brain CT Scan. In 57 hemiplegic patients, there wasn't any topographic predominance.3 hemiplegic. patients with, brachiofacial predominance of weakness and 5 patients with brachiofacial limited weakness had middle cerebral artery territory infarction, Although 1 patient with lower limb monoplegia had anterior cerebral artery territory infarction, but this topography led to hemiplegiain 2 others.

Alpha1 Antitrypsin (α1AT) is a glycoprotein which is synthesized in liver hepatocytes. It is an acute phase protein and its molecular weight is about 52 KD. This protein is expressed by two alleles on chromosome 14, codominantly. The most important function of this protein is the inhibition of serine proteases, therefore it is, classified in SERPIN (serine protease inhibitor) family. AAT has several alleles. These alleles are classified in normal (M1, M2, M3, M4, M5, ...), severe deficient (Z), moderate deficient (S), and null forms. Alpha1 Antitrypsin deficiency might be a risk factor for several diseases like neonatal and infantile liver disease, emphysema, asthma, arthristis rheumatic disease, glumeronephritis, and inflammatory eye disease.on the other hand, uveitis is an inflammatory eye disease. Immune system disorder, infectious disease, genetic and environmental factor might have important role in the etiology of this disease. Uveitis is divided in to anterior, posterior, panuveitis, and pars planitis forms. According to the role of immune system in uveitis and the regulation of this system by AAT, this research was designed. In this research 103 uveitis patients who referred to Zahedan Al-Zahra Ophthalmology center were investigated (from 1996 through 1998) and compared with 167 individuals without any eye or systemic disease. According to our result, in uveitis group 63 individuals had normal phenotypes (M1M2, M1M1 and M2M2), 14 M1S, 9 M2S, 10 M1Z, 3 MZ, and 4 MV phenotype. But in normal group, 160 individuals had normal phenotypes (M1M2, M1M1, and M2M2), 3 M1S, 1 M2S, and 3 M1Z phenotype. Therefore, there is a significant difference between abnormal phenotypes in patients and uveitis group (P<0.0001).

Our propose was to determine the incidence and evaluate the risk factors in postpartum glucose intolerance among women with gestation diabetes.Sixty gestational diabetics women underwent 2-hours glucose tolerance test in the puerprium.Nine patients (15%) were diabetic and eight (13%) showed impaired glucose tolerance. The requirement of insulin for glucose control during gestation and gestational age at diagnosis were significantly associated with abnormal postpartum glucose tolerance (P<0.0000, P<0.005).Pregnancies complicated by gestational diabetes are increased the risk of glucose intolerance during puerprium. Abnormal glucose tolerance occurs predominantly among those patients who require insulin therapy during the gestation or those diagnosed before 24 weeks gestation.

Ultrasound propagation velocity was measured experimentally in normal, benign and malignant breast tissues at various temperatures from 20 through 35°C, in order to distinguish tumors from normal breast tissue. In quantitative measurements of ultrasound velocity, 57 breast tissue specimens were selected, comprising 17 normal breast tissues, 20 benigns, and 20 malignant tumors. The cases were implanted in breast tissue mimicking materials and ultrasonic images (A-mode) at 20, 25, 30 and 35°C were processed and evaluated. It was observed that ultrasound propagation velocity in various temperatures is an important factor to distinguish in vitro specimens of benign and malignant from normal tissue (P-value<0.005). However, ultrasound velocities in malignant and benign tumors were very similar with almost complete overlap in all the temperatures. Evaluation of ultrasound velocities in all the temperatures showed that in normal breast tissue, benign and malignant tumors, ultrasound velocity increases with temperature linearly. In 20˚C, ultrasound velocities in benign and malignant specimens were differentiated slightly. Therefore, the results show the measurement of ultrasound velocities in normal breast tissue and malignant and benign tumors can be used in differentiation of tissues.

Amyloid Tumor is a phenomenon which is seen as primary or secondary rare lesions. These tumors have a wide distribution and were reported in several organs, especially bones, nervous system and lungs. We report the first published case of an Amyloid Tumor of Testis in 70 years old man.