Today’ S world is shifting the boundaries of truth amazingly, with reaching out the modern technologies including soft technologies, that are based on the intellectual property; human capital. And in the meantime, creativity, innovation, and in one word, "human talent" is the mainstay of these stunning developments. The softening of industry and the emergence of soft industries such as cultural and creative industries are the pivotal phenomenon of industries and technologies of our era. Accordingly, the issue of the talent management and factors affecting these industries, that are considered the industries of the whole brain, are of the great strategic importance. In this research, these factors were analyzed and prioritized in terms of effectiveness by identifying and explaining the twelve factors affecting the talent management, through strategy of the operational research and especially the DEMATEL technique, the most important of which include: " Approach of the Organizational Leaders and Managers ", "Organizational Culture", "Personnel Empowerment and Training Programs, " "Organizational Learning, " "Government Rules and Regulations, " and "Human Capital Characteristics".