The purpose this study was to investigate the effect of early maladaptive schemas, difficulty in emotional regulation and coping styles on of gender dysphoria in subgects undergoing gender Reassignment. The research design was descriptive-correlational. The statistical population consisted of all subjects with gender dysphoria who referred to Khorasan Razavi General Forensic Medicine Department during the legal stages of sex change during 2014-2016. One hundred participants were selected via convenience sampling, gave informed consent, They were asked to the questionnaires: Difficulties in Emotion Regulation (Gratz & Roemer, 2004), early maladaptive schema (Young, 1988), coping styles (Collins & Reed, 1990), and Gender identity disorder (Akafi, 2011). The data were analyzed by stepwise multiple regression. The results of this study showed that emotional deprivation, distrust, and emotional inhibition of the variable of early maladaptive schemas, Variables of limited strategies, difficulty of purposeful behavior, lack of emotional awareness, and impulse control difficulty of the variable of difficulty in emotional regulation and Emotion-focused coping styles of styles of coping with sexual dysphoria is a positive and significant relationship. Thus, the most important variables in predicting gender dysphoria were limited strategies, distrust, difficulty impulse control, and emotional deprivation (p<0/05). According to the findings of this study, the simultaneous role of cognitive and emotional factors in the occurrence of gender dysphoria in people seeking gender change is remarkable. And these variables can be used in therapeutic and educational interventions for this clinical population (p<0/05).