BACKGROUND AND OBJECTIVE: Treatment of cervical intraepithelial neoplasia (CIN) is the prevention of invasive carcinoma of the cervix. Treatment of CIN is destruction of abnormal epithelium which is a lower morbidity excision. Treatment options are dependent on experience of surgical team, severity of disease and kind of destruction procedure. The aim of this study was to compare the results of two methods, cryosurgery and loop electrosurgical excision procedure in the treatment of patients with CIN.METHODS: This clinical study was performed on 32 cases with CIN in Ghaem hospital and private clinic. A questionnaire included age of patients, severity of ON, type of management, follow-up of patients, the recurrence of disease and mortality of patients was used. After a cervicovaginal pap smear for every patient, cervical biopsy was carried out under colposcopic guidance and if indicated, ablation of abnormal epithelium was done. The patients randomly divided into two groups, 15 patients treated by cryosurgery and 17 patients by loop electrosurgical. After treatment, follow up was done at a 3 month interval for pelvic examination, pap smear and if indicated colposcopy directed biopsy was done cases. The results of these two methods were compared.FINDINGS: The mean age of patients was 35.97±10.8 years. The frequency of CIN were as follows: CIN II (43.2%), CIN I (35.1%) and CIN III (24.5%). Considering early complications, persistent disease and disease recurrence it was not seen any significant difference in each group. Considering early complications, persistent disease and disease recurrence, no significant difference was seen in each group. The cure rate with cryosurgery was 100% and with loop excision was 94.1% but there were no significant difference between two groups.CONCLUSION: Cryosurgery procedure for treatment of patients with CIN is more effective than loop electrosurgical procedure. Further studies with more samples are needed to evaluate the results of this procedure.