The purpose of the present study was to investigate the relationship between neuroticism, work-family conflict, role overload, procedural justice, distributive justice and job control with job burnout in employees of Ahvaz Gas Company. The participants of the study were 260 employees who completed questionnaire including NEO Personality Inventory, Work-Family Conflict, Role Overload, Organizational Justice, Job Control and job Burnout. The results indicated that there were significant positive relationship between neuroticism, work-family conflict and role overload with job burnout. Moreover, the significant negative relation was found between procedural justice, distributive justice and job control with Job burnout. The hierarchical regression analysis indicated that neuroticism, work-family conflict, role overload, procedural justice, distributive justice and job control accounts for approximately 77% of variance of job burnout. The stepwise regression analysis indicated that neuroticism and procedural justice predicted job burnout significantly.