Background: Research has been done on the relationship between emotion avoidance, physical well-being, body image dissatisfaction, anxiety, depression and stress, but the comparison of these variables with each other has been neglected. So the question is: Is there a difference between avoidance of experience, physical well-being, body image dissatisfaction, anxiety, depression and stress in cosmetic surgery applicants and non-cosmetic applicants? depression and stress among applicants and non-applicants of cosmetic surgery in Iran. Methot: The research method was causal-comparative. The statistical population of this study consisted of cosmetic surgery applicants referring to cosmetic clinics in district one and six of Shiraz municipality during the second 6 months of 2018 and students of Shiraz University (age range of 18-57 years). The sample of this study consisted of 200 individuals, including 100 applicants and 100 non-applicants, who were selected by non-random and convenience sampling method from among those who were eligible for the study The tools are: Littleton, Axom & Perry (2005), Body Image Fear Questionnaire, Behavioral Brown & Ryan Questionnaire (2003), Bond Acceptance and Commitment Questionnaire, Hayes & Zettel (2011) and Lovebond Depression, Anxiety and Stress Scale (1995). Data were analyzed by multivariate analysis of variance. Results: Results: There was a significant difference between the applicants for cosmetic surgery and the non-applicants for the variables under study (P< 0/001). Conclusions: It can be stated that dissatisfaction with body image, experiential avoidance, depression, anxiety and stress, as well as low level of hygiene can lead to increased cosmetic surgery.