Learning disability is a common problem in eductiond achievement and the most common learning disability is dyslexic disorder. The evidence indicated the influence of Gender Profile differences in Psychiatric Disorders Comorbidity in males and females Middle School Students. To assessm psychiatric comorbidity of comparative study was performed in Gender Profile Male amd Female adolescents with and without Dyslexic in Middle School Student in East region of Teheran. Participants included 400 Middle School Student (200 females and 200 males) The sample consisted of 400 adolescents, 200 with Dyslexic diagnosis and 200 with typical reading skills and abilities, screened from a larger sample in the public schools at age range of 15-16 years old who were selected by cluster sampling method from different school of East region of Teheran. All participants observed Dyslexic Scale, Psychiatric disorders checklist and other Psychiatric Questionnaire. There was significant difference between females and males in Gender Profile in Psychiatric Disorders comorbidity but both gender, obtained higher scores in ADHD. Psychiatric disorders in children with reading disorder have a higher comorbidity and gender profiles of psychiatric disorders in this children with reading disorder is different. The adolescent boys Disorder of ADHD; 34.7%, social anxiety; 15.4%, chronic depression; 13.5%, Conduct disorder; 13.5%, OCD, 11.6% and phobias1; 1.2% respectively rates of comorbidity with reading disorder, and adolescent girls in terms of prominence disorders ADHD, eating; 16.6%, OCD, 14.7%, specific phobia; 14.2%, generalized anxiety; 11.5%, and chronic depression; 10.8%, respectively, had the highest comorbidity.